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Open positions

Alex Evilevitch Research Group

We are always interested in reviewing applications from MSc students, prospective PhD students and postdocs.

Project description 

 

Herpesviruses are a leading cause of human viral disease. Herpesviruses consist of a double-stranded DNA genome contained within a protein shell, termed the capsid, that is surrounded by an unstructured protein layer and a lipid-envelope. Herpes Simplex virus type 1 (HSV-1) is a prototypical model system to study the general infection mechanisms of herpesviruses. We recently discovered a high internal DNA pressure of tens of atmospheres in HSV-1 capsids, resulting from tight genome confinement and repulsive DNA-DNA interactions. This pressure is capable of powering ejection of the entire viral genome. Using HSV-1 as our primary model system, you will investigate the roles of internal DNA pressure for viral replication. These studies will provide new insights into the key mechanisms facilitating as well as inhibiting viral infectivity. This research combines a quantitative biophysical approach to virology. Our laboratory uses experimental tools such as atomic force microscopy, microcalorimetry, fluorescence microscopy, light scattering, x-ray scattering and neutron scattering.  

For further informaiton regarding research projects contact Dr. Alex Evilevitch ( Alex [dot] Evilevitch [at] med [dot] lu [dot] se )  

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8 Mar 2021